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ONC-ORG

Hyper-CVAD

Hyperfractionated Cyclophosphamide, Vincristine, Doxorubicin, Dexamethasone alternating with High-Dose Methotrexate and Cytarabine · Intensive Leukemia / Lymphoma Protocol

Indications & Uses

Adult Acute Lymphoblastic Leukemia (ALL), Burkitt Lymphoma, and Mantle Cell Lymphoma.

Contraindications

Severe renal failure, baseline uncontrolled bacterial or fungal sepsis.

Side Effects & Warnings

Profound myelosuppression, mucositis, neurotoxicity, renal failure from methotrexate, opportunist infections.

Drug & Dietary Interactions

Extensive interactions; consult specific multi-agent administration and hydration protocols.

For educational and informational purposes only. Do not alter medication doses or regimens without consulting your licensed oncology physician or care team.

Patient & Caregiver Support

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