Neoadjuvant Combination Immunotherapy for Stage III Melanoma
University of Louisville · University of Louisville, Louisville, Kentucky
Determine safety and efficacy of pre-operative combination immunotherapy with Talimogene Laherparepvec (T-VEC)/Pembrolizumab given prior to complete lymph node dissection in resectable stage 3 cutaneous melanoma with clinically apparent lymph node metastases.
Eligibility: 18 Years to · All · * 18 years of age, any race or sex, who have pathologically confirmed cutaneous melanoma * ECOG performance status of 0 or 1 * Adequate hematologic, hepatic, renal and coagulation function * Must have measurable disease and have an injectable target lymph node for intralesional therapy administration * Primary melanoma has been resected * Pathologically confirmed resectable stage III disease, clinically apparent. Resectability is at the discretion of the treating surgeon who is a melanoma specialist. * Stage III disease can be at time of diagnosis of primary melanoma or a recurrence after initial treatment of stage I-II disease. * BRAF mutant or wild type allowed (mutations status not necessary for enrollment) * Signed, written informed consent