Atrophic Gastritis Predicts the Risk of Gastric Cancer
NCT06203327 · Phase II · Shanghai, Shanghai Municipality, China
- Condition
- Stomach Cancer
- Disease stage
- Stage I-IV
- Phase
- Phase II
- Study type
- OTHER
- Intervention
- Esophagogastroscopy (OLGA 0-Ⅰ)
- Age
- 18 Years to 70 Years
- Gender
- All
- Sponsor
- Shanghai Jiao Tong University School of Medicine
- Research institution
- Shanghai Jiao Tong University School of Medicine
- Facility
- Renji Hospital, School of Medicine, Shanghai Jiao Tong University
- Research center
- Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Summary
Despite declining incidence rates, gastric cancer (GC) ranks the fourth leading cause of cancer-related mortality and the fifth most common cancer worldwide, with the highest incidence reported in Eastern Asia. The 5-year overall survival rate of early GC exceeds 90%, which was well above advanced GC. Most intestinal-type GCs follow the Correa cascade-inflammation,atrophy, intestinal metaplasia (IM), dysplasia and subsequent carcinoma. The presence of gastric mucosal atrophy and intestinal metaplasia are important risk factors for GC. The purpose of this study was to investigate the incidence of GC attributed to atrophic gastritis in a region with high incidence of GC.
Inclusion criteria
* Ability and willingness to participate in the study and to sign and give informed consent * Biopsies were collected based on the recommendation of updated Sydney system
Exclusion criteria
* under 18 or over 80 years old * history of gastrectomy * severe systemic diseases or malignancy
Primary outcomes
early gastric neoplasm