Living Donor Liver Transplant for Unresectable Colorectal Liver Metastases
NCT05248581 · Phase II · Rochester, New York, United States
- Condition
- Liver Cancer
- Disease stage
- Stage I-IV
- Phase
- Phase II
- Study type
- PROCEDURE
- Intervention
- Liver transplantation
- Age
- 18 Years to
- Gender
- All
- Sponsor
- University of Rochester
- Research institution
- University of Rochester
- Facility
- University of Rochester Medical Center
- Research center
- University of Rochester Medical Center
Summary
The goal of this study is to create a data registry to capture clinical, pathologic, and molecular data/outcomes for patients with metastatic colorectal cancer who undergo live donor liver transplantation.
Detailed description
The goal of this study is to create a data registry to capture clinical, pathologic, and molecular data/outcomes for patients with metastatic colorectal cancer who undergo live donor liver transplantation. Our primary outcome of interest was the OS and recurrence-free survival (RFS) of patients who underwent LDLT at our center.
Inclusion criteria
* Age ≥ 18 * Non-amenable to curative hepatic resection as defined by FLR \<30% * Histologically confirmed adenocarcinoma of the colon or rectum * Candidate for LDLT for colorectal liver metastasis per the University of Rochester liver transplant program
Exclusion criteria
* Not a candidate of the LDLT liver transplant protocol for treatment of colorectal liver metastasis. * Unwilling to consent
Primary outcomes
percentage of patients with recurrence free survival; percentage overall survival